The prevalence of allergic inflammatory diseases such as atopic dermatitis, asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via mitogen-activated protein kinases (MAPKs)/NF-κB pathway in allergic inflammation.