Morphine dependence is attenuated by red ginseng extract and ginsenoside Rh2, Rg3, and compound K

Red ginseng and ginsenosides have shown plethoric effects against various ailments. However, little is known regarding to the effect of red ginseng against morphine-induced dependence and tolerance. We therefore investigated the effect of red ginseng extract (RGE) and biotransformed ginsenosides Rh2, Rg3 and compound K against morphine-induced dependence in mice and rats.