The impact of fungicide azoxystrobin applied as foliar spray on the physiological and biochemical indices and ginsenosides contents of ginseng was studied in ginseng (Panax ginseng Mey. cv. ‘Ermaya’) under natural environmental conditions. Different concentrations of 25% azoxystrobin SC (150g a.i. /ha and 225 g a.i. /ha) on ginseng plants were sprayed three times and the changes in physiological and biochemical indices and ginsenosides contents of ginseng leaves were tested.

Ginseng saponin has long been used as a traditional Asian medicine and is known to be effective in treating various kinds of pain. Ginsenoside Rf is one of the biologically active saponins found in ginseng. We evaluated ginsenoside Rf’s antinociceptive and anti-inflammatory effects, and its mechanism of action on adrenergic and serotonergic receptors, in an incisional pain model.

Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These finding also provide a part of molecular rationale for the role of Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.

The temperature is an essential condition in Red ginseng processing. Pharmacological activities of Red ginseng in different steam temperature are significantly different.

Recently, the protein from ginseng has been studied and used for the treatment of several kinds of diseases. However, the effect of ginseng total protein (GTP) on proliferation and wound-healing in fibroblast cells still remains unclear.

Extended endoplasmic reticulum (ER) stress may initiate apoptotic pathways in cancer cells, and ER stress has been reported to possibly increase tumor death in cancer therapy. We previously reported that caspase-8 played an important role in compound K-induced apoptosis via activation of caspase-3 directly or indirectly through Bid cleavage, cytochrome c release, and caspase-9 activation in HL-60 human leukemia cells. The mechanisms leading to apoptosis in A549 and SK-MES-1 human lung cancer cells and the role of endoplasmic reticulum (ER) stress have not yet been understood.

The study was done to assess the genetic variability present in Ashwagandha and to examine the nature of associations of various traits to the root yield of the plant.

Prenyltransferases catalyze the sequential addition of IPP units to allylic prenyl diphosphate acceptors and are classified as either trans-prenyltransferases (TPTs) or cis-prenyltransferases (CPTs). The functions of CPTs have been relatively well characterized in bacteria, yeast, and mammals compared to that of in plants. The characterization of CPTs also has been less studied than TPTs. In this present study, molecular cloning and functional characterization of a CPT from a medicinal plant, Panax ginseng Mayer are addressed.

Previously, we reported Korean Red Ginseng inhibited liver fibrosis in mice and reduced the expressions of fibrogenic genes in hepatic stellate cells (HSCs). The present study was undertaken to identify the major ginsenoside responsible for reducing numbers of HSCs and the underlying mechanism involved.

Ginseng effectively regulates the immune response and the hormonal changes due to stress, thus maintaining homeostasis. In addition to suppressing the occurrence of psychological diseases such as anxiety and depression, ginseng also prevents stress-associated physiological diseases. Recent findings have revealed that ginseng is involved in adjusting the hypothalamic-pituitary-adrenal axis and controlling hormones, thus producing beneficial effects on the heart and brain, and in cases of bone diseases, as well as alleviating erectile dysfunction.