The prevalence of allergic inflammatory diseases such as atopic dermatitis, asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via mitogen-activated protein kinases (MAPKs)/NF-κB pathway in allergic inflammation.
All posts by Ji-Ye Kee, Yong-Deok Jeon, Dae-Seung Kim, Yo-Han Han, Jinbong Park, Dong-Hyun Youn, Su-Jin Kim, Kwang Seok Ahn, Jae-Young Um, Seung-Heon Hong
Anticancer effect of joboksansam, Korean wild ginseng germinated from bird feces
Joboksansam, Korean bird wild ginseng, is an artificially cultivated wild ginseng germinated from bird feces. Although numerous pharmacologic activities of wild ginsengs have been reported, the beneficial effect of joboksansam in cancer has not been elucidated. In this study, we investigated the in vivo and in vitro anticancer activities of joboksansam powder.
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The inhibitory activity of ginsenoside Rp4 in ADP-induced platelet aggregation
Korean ginseng, Panax ginseng Meyer (P. ginseng), has been used as a traditional oriental medicine to treat illness and promote health for several thousand years. Ginsenosides are the main constituents for the pharmacological effects of P. ginseng. Since several ginsenosides, including G-Rg3 and G-Rp1, was reported the anti-platelet activity, here we investigated the ability of G-Rp4 to modulate ADP-induced platelet aggregation. The ginsenoside Rp4 (G-Rp4), a similar chemical structure of ginseoside Rp1, was prepared from G-Rg1 by chemical modification.
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The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet
The present study investigated the effect of ginseng berry hot water extract (GBx) on blood flow via regulation of lipid metabolites and blood coagulation in rats fed a high-fat diet (HFD).
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Ginsenoside Rc from exerts anti-inflammatory activity by targeting TBK1/IRF-3 and p38/ATF-2
Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anti-cancer, anti-inflammatory, anti-obesity, and anti-diabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects.
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Discrimination of American ginseng and Asian ginseng using electronic nose and GC-MS coupled with chemometrics
The American ginseng (Panax. Quinquefolius. L) and Asian ginseng (Panax. ginseng. Meyer) products, such as slices, show similar appearance, but they have significant different prices, leading to wide adulteration in commercial market. Their aroma characteristics are attracting increasing attention and supposed to be effective and non-destructive markers to determine adulteration.
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Metabolite profiles of ginsenosides Rk1 and Rg5 in zebrafish using UPLC-Q-TOF/MS
In present study, metabolite profiles of ginsenosides Rk1 and Rg5 from red ginseng or red notoginseng in zebrafish were qualitatively analyzed with the Ultraperformance Liquid Chromatography/Quadrupole -Time-of-Flight Mass Spectrometry, and then we put forward the possible metabolic pathways.
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Anti-aging effects of the mixture of and in human dermal fibroblasts and healthy human skin
Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to up regulation of MMP-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of Panax ginseng Meyer and Crataegus pinnatifida (GC) would have protective effects against skin aging.
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Comparative analysis of the transcriptomes and primary metabolite profiles of adventitious roots of five cultivars
Various Panax ginseng cultivars exhibit range of diversity for morphological and physiological traits. However there is less study on diversity of metabolic profiles and genetic background to understand the complex metabolic pathway in ginseng.
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anti-oxidative and anti-inflammatory effects of BIOGF1K, compound K-rich fraction, prepared from
BIOGF1K, a compound K-rich fraction prepared from the root of Panax ginseng is widely applied in cosmetic purpose in Korea. We firstly investigated the functional mechanisms of anti-inflammatory and anti-oxidative activities of BIOGF1K by discovering target enzymes through various molecular studies.
