Korean Red Ginseng (KRG) is an herbal medicine used in Asian countries and is very popular for its beneficial biological properties. Diabetes mellitus (DM) and its complications are rapidly becoming a global public health concern. The literature on transcriptional changes induced by KRG in rat models of diabetic retinopathy is limited. Considering these facts, we designed this study to determine whether retinopathy-associated genes are altered in DM rat retinas and whether the induced changes are reversed by KRG.
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Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
Ginsenoside Rg3 is a promising anticancer agent. It is usually produced by heat treating ginseng, in which ginsenoside Rb1 is the major ginsenoside. A kinetic study was conducted to optimize ginsenoside Rg3 production by the heat treatment of ginsenoside Rb1.
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Ginsenoside Re inhibits pacemaker potentials via ATP sensitive K channels and a cGMP/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine
Ginseng belongs to the genus Panax and its main active ingredients are called ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract. To understand the effects of ginsenoside Re (GRe) on GI motility, the authors investigated its effects on the pacemaker activities of ICCs of the murine small intestine.
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The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation
Korean Red Ginseng has been used as a traditional oriental medicine to treat illness and to promote health for several thousand years in Eastern Asia. It is widely accepted that ginseng saponins, ginsenosides, are major active ingredients for Red ginseng’s therapeutic activity against many kinds of illness. Although crude saponin fraction (CSF) displayed anti-platelet activity, the molecular mechanism of its action remains to be elucidated.
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Ginsenoside Rd and ischemic stroke; a short review of literatures
Panax ginseng is a well-known economic medical plant which is broadly used in Chinese traditional medicine. This species contains unique class of natural products, namely ginsenosides. Recent clinical and experimental studies lined a plethora of evidences up for the promising role of ginsenosides on different diseases including neurodegenerative, cardiovascular, certain types of cancer, etc. Nowadays, much attention has been paid to ginsenoside Rd as neuroprotective agent to attenuate ischemic stroke damages.
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Effects of steaming on saponin compositions and anti-proliferative activity of V ginseng
Steaming of ginseng is known to change its chemical composition and biological activity. This study was carried out to investigate the effect of different steaming time-scales on chemical constituents and anti-proliferative activity of Vietnamese ginseng (VG).
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Characteristics of Korean ginseng varieties of Gumpoong, Sunun, Sunpoong, Sunone, Chengsun, and Sunhyang
The Korea Ginseng Corporation (KGC) has developed six varieties of ginseng called Gumpoong, Sunun, Sunpoong, Sunone, Chengsun, and Sunhyang. Gumpoong shows no purple stem in the aerial section and the color of its berries and autumn leaves are distinctively yellow. In the testing of 4-yr old specimens in 2002, the proportions of the below ground roots that were rusty colored for Gumpoong was 1.29 in Daejeon and 1.45 in Eumseong; whereas the proportions for its yellow berry variant landrace were 2.60 and 2.45 in the two regions, respectively.
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Chemoprevention of chemical induced skin cancer by root extract
Cancer is emerged as a major health problem globally consequent to increase longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy against cancer burden. Recently, some natural products have been identified for their chemopreventive activity for the reduction in cancer incidences. Ginseng is known for its potential to treat various ailments in human beings. The present study was designed to explore the anticancer and anti-oxidative potential of Panax ginseng against chemical induced skin carcinogenesis in mammals.
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Red Ginseng extract blocks histamine-dependent itch by inhibition of H1R/TRPV1 pathway in sensory neurons
Korean Red Ginseng – a steamed root of Panax ginseng Meyer – has long been used as a traditional medicine in Asian countries. Its anti-pruritic effect was recently found, but no molecular mechanisms were revealed. Thus, the current study focused on determining the underlying molecular mechanism of Korean Red Ginseng extract (RGE) against histamine-induced itch at the peripheral sensory neuronal level.
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Administration of red ginseng ameliorates the memory decline in aged mice
It has been known that ginseng can be applied as a potential nutraceutical for memory impairment, however experiments with animals of old age are few.
