VASP-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to αIIb/β in thrombin-induced human platelets

Glycoprotein IIb/IIIa (αIIb/β3) is involved in platelet adhesion, and triggers a series of intracellular signaling cascade, leading to platelet shape change, granule secretion and clot retraction. In this study, we evaluated the effect of ginsenoside Ro (G-Ro) on the binding of fibrinogen to αIIb/β3.