Publication date: Available online 23 February 2026Source: Journal of Ginseng ResearchAuthor(s): Sang-Hoon Lee, Jae-Hee Kwon, Hyun-Woo Kim, Se Hwan Mun, Young Yang, Jihoon Kim, Kwang-Won Seo, Do-Kyun Kim, Young-Eun Cho
Publication date: Available online 24 February 2026Source: Journal of Ginseng ResearchAuthor(s): Meng Sun, Ying Liu, Meng-yang Wang, Wei Liu
Publication date: Available online 28 February 2026Source: Journal of Ginseng ResearchAuthor(s): Sung Ha Lim, Hee-Seok Seo, Hyun Kang, Seung-Phil Hong
Panax ginseng has been used in traditional medicine to strengthen the body and mental well-being of humans for thousands of years. Many elite ginseng cultivars have been developed, and ginseng cultivation has become well established during the last century. However, heat stress poses an important threat to the growth and sustainable production of ginseng. Efforts have been made to study the effects of high temperature on ginseng physiology, but knowledge of the molecular responses to heat stress is still limited.
Ginsenosides have been widely used clinically for many years and were regarded as very safe. However, a few researches on the toxicities of these kinds of agents showed that some ginsenosides may have side effect on the rats or dogs. So it is extremely necessary to further clarify the potential toxicity of ginsenosides. This study was carried out to investigate long-term toxicity and genotoxicity of 25-OCH3-PPD, a new derivative of ginsenoside, in beagle dogs.
Gintonin is a ginseng-derived exogenous ligand of the G protein-coupled lysophosphatidic acid (LPA) receptor. We previously reported that gintonin stimulates gliotransmitter release in primary cortical astrocytes. Astrocytes play key roles in the functions of neurovascular systems. Although vascular endothelial growth factor (VEGF) is known to influence the normal growth and maintenance of cranial blood vessels and the nervous system, there is little information about the effect of gintonin on VEGF regulation in primary astrocytes, under normal and hypoxic conditions.
Ginseng has been traditionally used for several millennia in Asian countries including Korea, China, and Japan, not only as a nourishing and tonifying agent but also as a therapeutic agent for a variety of diseases. In recent years, the various effects of red ginseng including immunity improvement, fatigue relief, memory improvement, blood circulation improvement, anti-oxidation, mitigation of menopausal women’s symptoms, and anti-cancer have been reported in clinical as well as basic research. Around the world, there is a trend of the rising consumption of health functional foods on the level of disease prevention along with increased interest in maintaining health because of population aging and the awareness of lifestyle diseases and chronic diseases.
The ginsenoside Rg3, one of active components of red ginseng, has chemopreventive and anti-cancer potential. Cancer stem cells (CSCs) retain self-renewal properties which account for cancer recurrence and resistance to anti-cancer therapy. In our present study, we investigated whether Rg3 as well as the standardized Korean red ginseng extract (RGE) could modulate the manifestation of breast cancer stem-like features through regulation of self-renewal activity.
Ginsenoside Rb1, a triterpene saponin, is derived from the Panax ginseng root and has potent anti-inflammatory activity. In this study, we determined if Rb1 can increase macrophage phagocytosis, and elucidated the underlying mechanisms.
As the main metabolites of ginsenosides, 20(S, R)-protopanaxadiol (PPD(S, R)) and 20(S, R)-protopanaxatriol (PPT(S, R)) are the structural basis response to a series of pharmacological effects of their parent components. Although the estrogenicity of several ginsenosides has been confirmed, however, the underlying mechanisms of their estrogenic effects are still largely unclear. In this work, PPD(S, R) and PPT(S, R) were assessed for their ability to bind and activate human estrogen receptor α (hERα) by a combination of in vitro and in silico analysis.
