Long-term ginseng intake can increase longevity in healthy individuals. Here we examined if long-term treatment with Panax ginseng C.A. Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with HIV-1 infection.

Korean Red Ginseng (KRG) is an ethnopharmacological plant that is traditionally used to improve the body’s immune functions and ameliorate the symptoms of various diseases. However, the anti-tumorigenic effects of KRG and its underlying molecular and cellular mechanisms are not fully understood in terms of its individual components. In this study, in vitro and in vivo anti-tumorigenic activities of KRG were explored in water extract (WE), saponin fraction (SF), and non-saponin fraction (NSF).

In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of Panax ginseng by microflora are important for obtaining a better understanding of their biological effects.

Chronic liver disease (CLD), one of the most common diseases, typically arises from non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma (HCC). Therefore, there is a pressing need for improved treatment strategies. Korean red ginseng (KRG) has been known to have positive effects on liver disease and liver function. In this paper, we summarize the current knowledge on the beneficial effects of KRG on CLD, a condition encompassing NAFLD, alcoholic liver disease, chronic viral hepatitis, and HCC, as supported by experimental evaluation and clinical investigation.

AD-2 (20(R)-dammarane-3b, 12b, 20, 25-tetrol; 25-OH-PPD) is a ginsenoside and isolated from P. ginseng, showing anticancer activity against extensive human cancer cell lines. In this study, effects and mechanisms of 1C ((20R)-3b-O-(L-alanyl)-dammarane-12b, 20, 25-triol), a modified version of AD-2, were evaluated for its development as a novel anticancer drug.

Saponins from Panax japonicus (SPJ) are the most abundant and main active components of Panax japonicus, which replaces Ginseng roots in treatment for many kinds of diseases in minority ethnic group in China. Our previous studies have demonstrated that SPJ has the effects of anti-inflammation through MAPK and NF-κB signaling pathway. The present study was designed to investigate whether SPJ can modulate intestine TJ barrier in aging rats and further to explore the potential mechanism.

Ginsenosides have been reported with many health benefits, including anti-inflammatory effects and the resolution of inflammation is now considered to be an active process driven by M2 type macrophages. In order to determine whether ginsenosides modulate macrophage phenotypes to reduce inflammation, 11 ginsenosides were studied with respect to macrophage polarization and the resolution of inflammation.